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Detection, prognosis and treatment

Delivering clinical solutions and new approaches to treatment.

Clinical advances for breast cancer will utilize novel imaging technologies, new biomarkers and genomic/proteomic approaches for more accurate diagnosis and prognosis.

We encourage projects whose aims are on the critical path for translation. We support research into less toxic and more individualized therapies, mechanisms of drug resistance and studies to evaluate alternative medicines and natural products. Specific topics for research in this area might include:

Imaging, biomarkers, and molecular pathology: Improving detection and diagnosis — We encourage research into new, cost-effective technological and biological approaches for molecular imaging and new approaches for tumor analysis at the individual patient level. This includes advanced types of molecular classification, new biomarker development, and improved technologies for patient diagnosis and prognosis, especially using techniques to replace the current practice of screening mammography and biopsy.

Innovative treatment modalities: Search for a cure — Promising leads from biology-based studies are encouraged to begin the critical path to clinical translation. Examples include immunotherapy, delivery technologies, gene therapy, new drug development/testing and new approaches to clinical decision-making. Testing investigational anti-breast cancer agents for mechanism of action and identifying target patient populations are encouraged.