Innovative Treatment Modalities: search for a cure: New drug design

Promising leads from biology-based studies are encouraged to begin the critical path to clinical translation. Examples include immunotherapy, delivery technologies, gene therapy, new drug development/testing, and new approaches to clinical decision-making


Inhibitors of Condensin I as Chemotherapy for Breast Cancer 2009 (Cycle 15)
  University of California, Irvine   $100,000
  Award Type: IDEA
 
A Predictive Factor for Eribulin Treatment of Breast Cancer 2009 (Cycle 15)
  University of California, Santa Barbara   $76,000
  Award Type: Dissertation
 
Engineering EGFR Antagonists for Breast Tumor Targeting 2007 (Cycle 13)
  Stanford University   $75,992
  Award Type: Dissertation
 
rADDs: Novel Disintegrins Targeting Breast Cancer 2006 (Cycle 12)
  University of Southern California   $244,500
  Award Type: IDEA
 
Inhibition of Brain Metastases in Breast Cancer 2006 (Cycle 12)
  Scripps Research Institute   $464,750
  Award Type: IDEA-competitive renewal
 
Nur77-derived Peptides as a Novel Breast Cancer Therapy 2006 (Cycle 12)
  The Burnham Institute for Medical Research   $286,500
  Award Type: IDEA
 
Chemical Inhibitors of Hsp70 for Breast Cancer 2006 (Cycle 12)
  The Burnham Institute for Medical Research   $103,232
  Award Type: Postdoctoral Fellowship
 
Inhibition of Brain Metastases in Breast Cancer 2005 (Cycle 11)
  Scripps Research Institute   $278,850
  Award Type: IDEA
 
HER3 Infidelity and Resistance to Tyrosine Kinase Inhibitors 2005 (Cycle 11)
  University of California, San Francisco   $150,000
  Award Type: IDEA
 
Inhibition of the BRCA2-RAD51 Interaction in Breast Cancer 2005 (Cycle 11)
  University of California, Irvine   $134,769
  Award Type: Postdoctoral Fellowship
 
cAMP Antagonists of Protein Kinase as Breast Cancer Drugs 2005 (Cycle 11)
  Scripps Research Institute   $48,253
  Award Type: Postdoctoral Fellowship
 
FKBP Proteins as Molecular Targets in Breast Cancer Therapy 2004 (Cycle 10)
  California Pacific Medical Center Research Institute   $88,906
  Award Type: Postdoctoral Fellowship
 
Inhibition of Breast Cancer Cell Invasion by Natural Indoles 2003 (Cycle IX)
  University of California, Berkeley   $80,000
  Award Type: Postdoctoral Fellowship
 
Dietary Indole Analogs Inhibit Breast Cancer Cell Invasion 2003 (Cycle IX)
  SRI International   $381,491
  Award Type: STEP
 
Inhibitors of Myc: Novel Drugs for Breast Cancer 2003 (Cycle IX)
  Scripps Research Institute   $277,887
  Award Type: STEP
 
Novel I3C Regulated Cell Cycle Factor in Breast Cancer Cells 2003 (Cycle IX)
  University of California, Berkeley   $150,000
  Award Type: STEP
 
Regulation of SXR and Drug Resistance in Breast Cancer 2002 (Cycle VIII)
  Beckman Research Institute of the City of Hope   $41,984
  Award Type: Dissertation
 
Retinoids in Combination Therapies against Breast Cancer 2002 (Cycle VIII)
  Sidney Kimmel Cancer Center   $389,000
  Award Type: STEP
 
Potential New Drug Therapy for Breast Cancer 2002 (Cycle VIII)
  University of California, San Francisco   $199,740
  Award Type: STEP
 
MMP-Directed Synthesis of Invasive Breast Cancer Blockers 2002 (Cycle VIII)
  Scripps Research Institute   $135,298
  Award Type: IDEA
 
Novel Retinoids with Enhanced Anti-Breast Tumor Efficacy 2002 (Cycle VIII)
  The Burnham Institute for Medical Research   $378,972
  Award Type: STEP
 
TR3-based Peptides for Apoptosis in Breast Cancer 2002 (Cycle VIII)
  The Burnham Institute for Medical Research   $380,825
  Award Type: STEP
 
Blood Vessel Markers in Breast Cancer 2001 (Cycle VII)
  The Burnham Institute for Medical Research   $378,655
  Award Type: STEP
 
Enhanced HER-2 Directed Liposomal Therapeutics 2001 (Cycle VII)
  California Pacific Medical Center Research Institute   $332,938
  Award Type: New Investigator
 
Protein Factor PPARg & Vitamin A Compounds in Breast Cancer 2001 (Cycle VII)
  The Burnham Institute for Medical Research   $85,218
  Award Type: Postdoctoral Fellowship
 
PPARd Ligands for Inhibition of Breast Cancer Progression 2001 (Cycle VII)
  SRI International   $192,842
  Award Type: STEP
 
Targeting the EphB4 Receptor to Inhibit Breast Tumor Growth 2001 (Cycle VII)
  The Burnham Institute for Medical Research   $184,576
  Award Type: STEP
 
Targeted Delivery of an Anti-breast Tumor Agent 2000 (Cycle VI)
  University of Southern California   $684,291
  Award Type: TRC Full
 
Computer-Aided Discovery of Novel Breast Cancer Therapeutics 2000 (Cycle VI)
  Molecular Research Institute   $112,041
  Award Type: SPRC Exploratory
 
Novel Anti-Angiogenic Agents for Breast Cancer Therapy 2000 (Cycle VI)
  SRI International   $366,022
  Award Type: IDEAS II
 
Arginine Deiminase as an Innovative Anti-Breast Cancer Agent 2000 (Cycle VI)
  University of Southern California   $81,507
  Award Type: IDEA
 
SXR: A Novel Target for Breast Cancer Therapeutics 1999 (Cycle V)
  University of California, Irvine   $58,132
  Award Type: Postdoctoral Fellowship
 
Novel Breast Cancer Anti-Angiogenic Compounds 1999 (Cycle V)
  University of California, Los Angeles   $67,611
  Award Type: IDEA
 
Laboratory Testing of Chinese Herbs Used for Breast Cancer 1999 (Cycle V)
  University of California, San Francisco   $85,754
  Award Type: IDEAS II
 
Novel Anti-vascular Agents for Breast Cancer Therapy 1998 (Cycle IV)
  SRI International   $353,908
  Award Type: ITaMoCAs
 
Mechanism of Novel Anti-Angiogenic Therapy for Breast Cancer 1998 (Cycle IV)
  University of Southern California   $324,300
  Award Type: ITaMoCAs
 
Reduced Breast Cancer Metastasis by Conjugated Linoleic Acid 1998 (Cycle IV)
  University of California, Davis   $199,627
  Award Type: ITaMoCAs
 
A New System for Breast Cancer Drug Delivery 1998 (Cycle IV)
  California Pacific Medical Center Research Institute   $73,185
  Award Type: Postdoctoral Fellowship
 
Heregulin-specific Diphtheria Toxin as a Cancer Therapy 1998 (Cycle IV)
  Salk Institute for Biological Studies   $322,293
  Award Type: New Investigator
 
Blocking Stromelysin-3 to Inhibit Breast Cancer Metastasis 1997 (Cycle III)
  SRI International   $358,783
  Award Type: ITaMoCAs
 
Superfibronectin: A Novel Anti-Breast Cancer Agent 1997 (Cycle III)
  The Burnham Institute for Medical Research   $389,026
  Award Type: ITaMoCAs
 
Novel drugs to inhibit breast cancer metastasis 1997 (Cycle III)
  University of California, Santa Cruz   $197,064
  Award Type: ITaMoCAs
 
Novel Enzyme Inhibitors for Estrogen-Dependent Breast Cancer 1997 (Cycle III)
  SRI International   $364,820
  Award Type: ITaMoCAs
 
Targeting Breast Cancer Using Diphtheria Toxin 1996 (Cycle II)
  Salk Institute for Biological Studies   $375,052
  Award Type: ITaMoCAs
 
Structure of EST1: A potential Drug Target for Breast Cancer 1996 (Cycle II)
  University of California, Berkeley   $50,000
  Award Type: ITaMoCAs
 
Novel retinoids that induce apoptosis in breast cancer cells 1996 (Cycle II)
  Sidney Kimmel Cancer Center   $377,091
  Award Type: ITaMoCAs
 
EGFR Structure for Drug Design Targeted to Breast Cancer 1995 (Cycle I)
  University of California, San Diego   $68,730
  Award Type: Postdoctoral Fellowship
 
Growth Inhibition of Breast Cancer Cells by Interferons 1995 (Cycle I)
  University of California, Los Angeles   $225,000
  Award Type: New Investigator
 
Breast Cancer Progression and the Extracellular Matrix 1995 (Cycle I)
  University of Southern California   $493,643
  Award Type: Research Project
 
Molecular Design for Prevention of Breast Cancer Progression 1995 (Cycle I)
  Cancer Research Institute of Contra Costa   $661,487
  Award Type: Research Project